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With the mission of "Green technology to achieve healthy life", we take the lead in applying synthetic biotechnology to the full green commercial production of "life molecules" raw materials with amino acids, nucleotides and sugars as monomers, focusing on creating innovative products and business solutions for industries such as big health, new consumption and green agriculture.

UltraHeal-P4P7

INCI Name: Palmitoyl Tetrapeptide-7

CAS: 221227-05 -0

Molecular Formula: C34H62N8O7

UltraHeal-P4P7 is a synthetic peptide derived from immunoglobulin G, known for its outstanding soothing and skin-tightening effects.


Product Information:

Immunoglobulin G (IgG) is the predominant immunoglobulin in human serum and serves as the primary antibody in the immune response. Palmitoyl tetrapeptide-7 is a palmitoylated derivative of the Gly-Gln-Pro-Arg (GQPR) tetrapeptide, derived from the structural fragments of the IgG. GQPR tetrapeptide can stimulate macrophages and granulocytes, enhancing phagocytic activity. Additionally, the GQP sequence is commonly found in type IV collagen. As a potent skin conditioner, palmitoyl tetrapeptide-7 (UltraHeal-P4P7) inhibits the secretion of pro-inflammatory cytokines (such as IL-6), and promotes the synthesis of key extracellular matrix components including laminin, fibronectin, and collagen. This results in reduced skin wrinkles, improved skin texture, and provides notable soothing and tightening effects.


Palmitoyl tetrapeptide-7


Efficacy:


Palmitoyl tetrapeptide-7


Experimental conditions: Mouse mononuclear macrophages; Blank control: Complete culture medium; Negative control: Bacterial lipopolysaccharide (LPS); Positive control: LPS+Dexamethasone; Experimental group: LPS+Palmitoyl tetrapeptide-7

Results: Palmitoyl tetrapeptide-7 can inhibit the secretion of inflammatory factor TNF-α and has a soothing effect.


Palmitoyl tetrapeptide-7


Palmitoyl tetrapeptide-7


Experimental conditions: hairless mouse skin; Blank control: placebo; Positive control: PM10; Experimental group: PM10+Palmitoyl tetrapeptide-7.

Experimental results: Palmitoyl tetrapeptide-7 can inhibit IL-6 induced by PM10 and has a soothing effect.

Reference:M.K. Kim et al., Asian J. Beauty Cosmetol., 2021, 19, 165–174


Palmitoyl tetrapeptide-7


Palmitoyl tetrapeptide-7


Experimental conditions: Blank control: No product used; Negative control: Placebo; Positive control: trans retinoic acid

Conclusion: Palmitoyl tetrapeptide-7 can promote the synthesis of fibrin-1 and has anti-aging effect.

Reference: R.E. Watson et al., Br. J. Dermatol., 2009, 161, 419–426.


Formulation Guidelines:

–  Recommended level of use: 10−100 ppm

–  UltraHeal-P4P7 is slightly soluble in water

–  UltraHeal-P4P7 has high biological activity, and should be processed below 45 °C and added at the final stage of formulation.