INCI Name: Tripeptide-29

CAS: 2239-67-0

Molecular Formula: C₁₂H₁₉N₃O₅

Gly-Pro-Hyp is the core fragment of collagen, which can promote collagen synthesis and has firming, soothing and moisturizing effects.

Product Information:

Collagen is the primary component of the skin’s dermis, accounting for approximately 75% of the skin’s dry weight. Among its structure, the tripeptide Gly-Pro-Hyp is the most critical fragment, with a repetition rate of over 10%. This tripeptide plays a key role in maintaining the stability of collagen’s triple-helix structure, enhancing its strength and elasticity. Compared to traditional large-molecule collagen, WrinFix-T29 offers superior skin penetration and high bioavailability, it has outstanding firming, moisturizing, and soothing benefits.

Efficacy:

"*" indicates significant difference compared with blank control, "*": p<0.05

Experiment condition: Human fibroblasts; Blank control: PBS solution; Positive control: 50 ng/mL TGF-β; Test group: 500 ppm WrinFix-T29

Result: WrinFix-T29 can boost multiple types of collagen (I, III, IV, and VII), providing anti-wrinkle and firming effects.

Promote filaggrin synthesis

In vitro【Keratinocytes】

Blank control: Cell culture medium; Positive control: 0.5% Hyaluronic acid; Test group: WrinFix-T29

Anti-inflammation

In vitro【RAW264.7】

Blank control: Cell culture medium; Negative control: LPS; Positive control: 100 ppm DEX; Test group: 500 ppm WrinFix-T29

Experiment conditions: Healthy Asian women (Age: 46.4± 1.2) N=32 ; Test group: 0.1% WrinFix-T29 essence, once a day, for 28 consecutive days

Result: 0.1% WrinFix-T29 essence can significantly improve skin firmness, increase stratum corneum hydration, and reduce redness, offering firming, soothing, and moisturizing benefits.

Formulation Guidelines:

– Recommended level of use: 0.05−1%

– pH adaptability: 3.0−7.0.

– Formulation guide: WrinFix-T29 is easily soluble in water and has good compatibility with other ingredients.