INCI Name: Nicotinamide Adenine Dinucleotide (NAD⁺)

CAS: 53-84-9

Molecular Formula: C₂₁H₂₇N₇O₁₄P₂

NAD⁺ is the key coenzyme for vitality, which is essential for energy metabolism, mitochondrial protection, anti-aging, and repair.

Product Information:

Nicotinamide adenine dinucleotide (NAD⁺), also known as Coenzyme I, is one of the most essential coenzymes in the human body. It is widely distributed in skin cells, but its levels decline with cellular aging. Mitochondria, the cell's energy powerhouse, rely on the TCA cycle and the electron transport chain to produce ATP, processes that are critically dependent on NAD⁺. Aging slows energy metabolism, halts the cell cycle, and impairs function. Supplementing NAD⁺ boosts ATP production, revitalizes cells, enhances mitochondrial activity, and aids repair, making it a powerful anti-aging ingredient.

Efficacy:

Experiment conditions: Control: Cell culture medium; Model group: H₂O₂; Test group: 100 ppm NAD⁺, 100 ppm NMN

Result: 100 ppm NAD⁺ can promote ATP production by 19%.

Experiment conditions: Control: Cell culture medium; Negative control: H₂O₂; Positive control: Ergothioneine; Test group: NAD⁺, NMN

Result: 10 ppm NAD+ has a restorative effect on mitochondrial damage.

Experiment conditions: Control: Cell culture medium; Model group: UVB; Test group: NAD⁺, NMN

Result: 100 ppm NAD⁺ can repair about 14% of UV-damaged cells.

Safety:

Pre-reaction photo of the 0.5% NAD⁺

Post-reaction photo of the 0.5% NAD⁺

The result of HET-CAM test shows that the irritation score (IS) of 0.5% NAD⁺ was 0.24 and it was non-irritating.

Formulation Guidelines:

– Recommended level of use: 10−1000 ppm;

– NAD⁺ has good water solubility (40 mg/mL);

– NAD⁺ has high biological activity. The operating temperature of the preparation process should be ≤ 45 °C. It should be added in the final stage of the formulation system.